PT-141, also known as Bremelanotide, is a synthetic melanocortin peptide derived from the α-MSH (alpha-melanocyte–stimulating hormone) sequence. In research settings, PT-141 functions as an MC4R and MC1R receptor agonist, activating central melanocortin pathways involved in neural signaling, autonomic function, and behavioral modulation.
Unlike compounds that influence vascular pathways, PT-141 interacts directly with central nervous system melanocortin circuits, making it a valuable tool for laboratory studies examining neuroendocrine signaling, receptor activation, and melanocortin-mediated physiological processes.
This peptide has been widely studied in preclinical and clinical research models investigating its role in melanocortin receptor signaling, neuroimmune interactions, and autonomic response pathways. PT-141’s activity at MC4R in particular allows researchers to explore mechanisms related to motivation, sympathetic nervous system activation, and hypothalamic regulatory functions.
PT-141 Structure:
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.182 g/mol
PubChem ID: 9941379
CAS Number: 189691-06-3
