KPV (Ac-Lys-Pro-Val-NH₂) is a synthetic tripeptide representing the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). This compact peptide is widely used in laboratory settings for its stability, ease of cell permeability, and its relevance in studying molecular pathways connected to inflammation regulation and cellular stress responses.
In vitro and ex vivo models use KPV to investigate how α-MSH–derived fragments interact with inflammatory mediators, epithelial barrier function, and signaling cascades such as NF-κB and cytokine modulation. Researchers have also examined KPV’s potential involvement in wound-healing models, peptide–receptor interactions, and melanocortin-related biochemical mechanisms.
Primary Research Areas:
- α-MSH fragment analysis and melanocortin-related mechanisms
- Inflammatory signaling pathways (e.g., NF-κB modulation models)
- Epithelial barrier and mucosal integrity studies
- Wound-repair and tissue-response mechanisms
- Cytokine expression and immune-modulation research
- Cell-penetration and peptide transport investigations
- Preclinical models of oxidative and inflammatory stress
KPV Structure:
Molecular Formula: C17H32N6O4
Molecular Weight: 384.48 g/mol
PubChem ID: 125672
CAS Number: 112965-21-6
