SLU-PP-332 is a synthetic small-molecule agonist targeting the estrogen-related receptor (ERR) family, a group of orphan nuclear receptors involved in cellular energy metabolism and mitochondrial regulation. In controlled laboratory studies, SLU-PP-332 demonstrates potent activation across all three primary ERR isoforms—ERRα, ERRβ, and ERRγ—making it a well-established pan-ERR agonist for advanced metabolic and mitochondrial research.
Experimental data show that SLU-PP-332 may upregulate transcriptional networks associated with fatty-acid oxidation, oxidative phosphorylation, and mitochondrial biogenesis, resulting in increased mitochondrial output and enhanced metabolic signaling in cellular models. This compound is widely utilized in studies exploring pathways related to exercise-mimetic mechanisms, energy expenditure, and mitochondrial adaptation.
Primary Research Areas:
- Pan-ERR agonism (ERRα, ERRβ, ERRγ)
- Mitochondrial biogenesis and respiration studies
- Fatty-acid oxidation pathways
- Oxidative-phosphorylation gene upregulation
- Exercise-mimetic signaling mechanisms
- Nuclear-receptor transcriptional regulation
- Cellular energy-metabolism models
SLU-PP-32 Structure:
Molecular Formula: C18H14N2O2
Molecular Weight: 290.3 g/mol
PubChem ID: 5338394
CAS Number: 303760-60-3
Synonyms: CHEMBL4208749
