MOTS-c (Mitochondrial ORF–encoded Peptide) is a 16–amino acid peptide encoded within the mitochondrial 12S rRNA region. Classified as a mitochondrial-derived peptide (MDP), MOTS-c is widely utilized in experimental research exploring cellular energy regulation, metabolic signaling, and mitochondria-to-nucleus communication.
In controlled laboratory environments, MOTS-c is frequently examined for its ability to modulate AMPK-related pathways, influence glucose-handling mechanisms, and participate in cellular responses to metabolic stress. Research also investigates how MOTS-c may translocate to the nucleus to affect gene-expression patterns linked to mitochondrial biogenesis, homeostasis, and adaptive metabolic regulation.
Its structural stability, predictable binding characteristics, and unique mitochondrial origin make MOTS-c a valuable tool for studies involving bioenergetics, stress-response signaling, and peptide-regulated metabolic pathways.
All production is performed under strict laboratory conditions with third-party verification to ensure high purity and consistency.
Primary Research Areas:
- AMPK pathway activation and metabolic signaling
- Mitochondrial-derived peptide (MDP) communication
- Glucose-regulation and energy-homeostasis models
- Metabolic-stress response pathways
- Mitochondrial biogenesis and nuclear translocation studies
- Skeletal muscle cellular signaling mechanisms
MOTS-c Structure:
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 g/mol
PubChem ID: 255386757
CAS Number: 1627580-64-6
Synonyms: Mitochondrial open reading frame of the 12S rRNA-c, 12S rRF-encoded mitochondrial peptide
