Tesofensine is a synthetic small molecule classified as a triple monoamine reuptake inhibitor, meaning it blocks the presynaptic reuptake of dopamine, norepinephrine, and serotonin in controlled experimental systems. Originally derived from the phenyl tropane family of compounds, Tesofensine has been widely used in laboratory research to explore neurotransmitter regulation, synaptic transmission, and central nervous system signaling.
In preclinical models, Tesofensine is frequently examined for its impact on monoaminergic balance, reward-pathway signaling, and neurochemical modulation. Its ability to influence multiple neurotransmitter pathways simultaneously makes it a valuable tool for studying complex CNS mechanisms, including receptor–transporter interactions and synaptic plasticity.
Tesofensine’s structural stability and predictable binding characteristics contribute to its usefulness in in vitro pharmacology, neuroscience research, and mechanistic studies involving neurotransmitter reuptake inhibition.
Primary Research Areas:
- Monoamine reuptake inhibition (dopamine, norepinephrine, serotonin)
- Synaptic transmission and neurotransmitter regulation studies
- Phenyl tropane structure–activity relationship (SAR) analysis
- Reward circuitry and neurochemical signaling pathways
- Transporter binding dynamics (DAT, NET, SERT)
- CNS stimulation and neurotransmission modeling
- Comparative studies with other reuptake inhibitors
Tesofensine Structure:
Molecular Formula: C17H23ClNO
Molecular Weight: 3.277 g/mol
PubChem ID: 11370864
CAS Number: 195875-84-4 (Depracated: 402856-42-2)
Synonyms: TE, NS-2330
